葛慎光
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葛慎光，教授，博士生导师，主要从事化学与生物传感、光电化学生物分析、疾病/癌症精准诊断策略开发、纳米材料及生物应用等领域研究。主持国家自然科学基金5项，山东省优青项目1项，山东省重点研发计划2项等项目10余项，获批山东省高等学校优秀青年创新团队1项，济南市科研带头人工作室1项；以第一作者或通讯作者在 Analytical Chemistry、Biosensors and Bioelectronics、Applied Catalysis B: Environmental等期刊发表 SCI收录论文100余篇；第一发明人和指导学生获授权发明专利30余项；获山东省自然科学一等奖1项，中国石油和化学工业联合会科技进步二等奖1项，中国分析测试协会科学技术二等奖1项等奖励；指导学生获得“挑战杯”全国大学生课外学术科技作品竞赛一等奖等国家级及省级科创奖励多项。
主讲课程：分析化学、生物分析、新型功能材料
科研方向：
1. 化学与生物传感
2. 光电化学生物分析
3. 纳米材料及生物应用
主持部分项目：
1.国家自然科学基金面上项目-可编程CRISPR/Cas响应DNA水凝胶纸芯片制备及病原体核酸检测-（22274065）
2.国家自然科学基金面上项目-可编程DNA步行者双极电极纸芯片构建及循环肿瘤DNA检测-(22074053)
3. 国家自然科学基金面上项目-纸芯片甄别检测高侵袭恶性循环肿瘤细胞的新方法-(21775055）
4. 国家自然科学基金面上项目-基于中空通道纸芯片的自推进分离捕获循环肿瘤细胞及原位分析-( 21575051)
5. 国家自然科学基金青年基金-基于点击化学的微囊藻毒素化学传感器构建-（21207048)
6. 山东省自然科学基金-纸基双极电极DNA步行者电化学发光平台构建及非小细胞肺癌标志物检测(ZR2024MB151)。
7. 山东省优青项目-多功能纸芯片分离捕获外周血中肿瘤细胞及原位分析-（ZR2015JL006）
8. 山东省高等学校青创科技支持计划-纸芯片即时检测方法与应用-（2019KJC016）
9. 山东省重点研发计划-原发性肝癌快速检测辅助诊断纸芯片试剂盒研制-（2018GGX103037）
10. 济南市“高校20条”资助项目科研带头人工作室-纸芯片液体活检技术及应用-（2020GXRC047）
科技获奖：
1. 基于结构调控和光电性能的纸芯片微流控基础研究与传感机制，山东省自然科学一等奖。
2. 纸芯片生物传感分析新方法及应用，中国分析测试协会科学技术二等奖。
3. 纸芯片传感器纳米材料构建传感界面和实现信号放大，山东省高等学校优秀科研成果一等奖。
4. 微流控纸芯片的功能调控技术及其应用，中国石油与化学工业联合会二等奖。
5. 基于外泌体的肿瘤液体活检分子标志物的研究及应用，山东省医学会青年科技奖。
代表性论文：
1. Ruifang Liu, Chengxiang Li, Longfei Zhu, Shujing Wang, Dandan Liu, Li Xie, Shenguang Ge*, Jinghua Yu, Cu Single-Atom Nanozymes Mediated Electrochemiluminescence Biosensor for Highly Sensitive Detection of MicroRNA-622, Analytical Chemistry, 2024, 96, 12838−12845.
2. Shujing Wang, Juan Wang, Longfei Zhu, Chengxiang Li, Jinxiang Wu, Shenguang Ge*, Jinghua Yu, Aptamer Responsive DNA Functionalized Hydrogels Electrochemiluminescence Biosensor for the Detection of Adenosine Triphosphate, Biosensors and Bioelectronics, 2024, 261, 116476.
3. Tingting Liu, Chunli Xu, Dicheng Ma, Lidong Cao, Shenguang Ge*, and Yuanbo Li, Glycine-doped metal-organic framework as intelligent nanocarriers to enhance pesticide delivery and provide micronutrient, Chemical Engineering Journal, 2024, 495, 153287.
4. Yanhu Wang, Mengchun Yang, Kang Cui, Lina Zhang, Xiao Wang, Shenguang Ge*, Jinghua Yu, Zhenxiang Cheng, Band Engineering of BiFeO3 Nanosheet for Boosting Hydrogen Evolution by Synergetic Piezo-photocatalysis, ACS Sustainable Chemistry & Engineering, 2024, 12, 2300−2312.
5. Lu Zhang, Zuhao Zhang, Ruifang Liu, Shujing Wang, Li Li, Peini Zhao, Yanhu Wang, Shenguang Ge*, Jinghua Yu，Entropy-driven catalysis cycle assisted CRISPR/Cas12a amplification photoelectrochemical biosensor for miRNA-21 detection，Sensors & Actuators: B. Chemical, 2023, 394, 134334.
6. Zuhao Zhang, Lu Zhang, Shujing Wang, Ruifang Liu, Li Li, Peini Zhao, Chaomin Gao, Fengming Chen, Shenguang Ge*, Jinghua Yu, Programming DNA walker and DNA tetrahedral nanostructures mediated CRISPR/Cas12a electrochemiluminescence biosystem and its biosensing application, Sensors & Actuators: B. Chemical, 2023, 396, 134644.
7. Hongmei Yang, Jiajun Wang, Haihan Yu, Xiao Li, Zhenglin Li, Kang Cui, Lina Zhang, Shenguang Ge*, Jinghua Yu, FeOOH/Cu2O/CuS photocathode-enabled simultaneous promotion on charge carrier separation and electron acceptor reduction for lab-on-paper homogeneous cathodic photoelectrochemical bioassay, Chemical Engineering Journal, 2022, 430, 132846.
8. Chuan Huang, Lu Zhang, Yuanna Zhu, Zuhao Zhang, Yunqing Liu, Chao Liu, Shenguang Ge*, Jinghua Yu, Dual-Engine Powered Paper Photoelectrochemical Platform Based on 3D DNA Nanomachine-Mediated CRISPR/Cas12a for Detection of Multiple miRNAs, Analytical Chemistry, 2022, 94, 8075−8084.
9. Yunqing Liu, Xuefeng Wang, Yuanna Zhu, Haiqing Wang, Jinghua Yu, Hong Liu, Shenguang Ge*, Reprogramming thermodynamic-limiting oxidation cycle in NiFe-based oxygen evolution electrocatalyst through Mo doping induced surface reconstruction, Journal of Colloid & Interface Science, 2022, 622, 443-451.
10. Fangfang Wang, Yunqing Liu, Cuiping Fu, Na Li, Miao Du, Lina Zhang*, Shenguang Ge*, and Jinghua Yu, Paper-Based Bipolar Electrode Electrochemiluminescence Platform for Detection of Multiple miRNAs, Analytical Chemistry, 2021, 93, 1702−1708.
11. Jinge Zhao, Cuiping Fu, Chuan Huang, Sibao Zhang, Fangfang Wang, Yan Zhang, Lina Zhang, Shenguang Ge*, Jinghua Yu, Co3O4-Au Polyhedron Mimic Peroxidase- and Cascade Enzyme-assisted Cycling Process-Based Photoelectrochemical Biosensor for Monitoring of miRNA-141, Chemical Engineering Journal, 2021, 406, 126892.
12.Yanhu Wang, Huihui Shi, Lina Zhang, Shenguang Ge*, Meiling Xu, Xiao Wang, Jinghua Yu, Two-dimensional black phosphorus nanoflakes: a coreactant-free electrochemiluminescence luminophors for selective Pb2+ detection based on resonance energy transfer, Journal of Hazardous Materials, 2021, 403, 123601.
13.Haihan Yu, Xiaoran Tan, Shubo Sun, Lina Zhang, Chaomin Gao, Shenguang Ge*, Engineering paper-based visible light-responsive Sn-self doped domed SnO2 nanotubes for ultrasensitive photoelectrochemical sensor, Biosensors and Bioelectronics, 2021, 185, 113250.
14.Qian Wang, Yaqi Liu, Jixian Yan, Yunqing Liu, Chaomin Gao, Shenguang Ge*, Jinghua Yu, 3D DNA Walker-Assisted CRISPR/Cas12a Trans-Cleavage for Ultrasensitive Electrochemiluminescence Detection of miRNA-141, Analytical Chemistry, 2021, 93, 13373−13381
15. Yanhu Wang, Huihui Shi, Kang Cui, Lina Zhang, Shenguang Ge*, Jinghua Yu, Reversible Electron Storage in Tandem Photoelectrochemical Cell for Light Driven Unassisted Overall Water Splitting, Applied Catalysis B: Environmental, 2020, 275: 119094.
16. Shaopeng Wang, Fangfang Wang, Cuiping Fu, Yina Sun, Jinge Zhao, Na Li, Yunqing Liu, Shenguang Ge*, Jinghua Yu, AgInSe2-Sensitized ZnO Nanoflowers Wide Spectrum Response Photoelectrochemical/Visual Sensing Platform via Au@Nanorods-Anchored CeO2 Octahedron Regulated Signal, Analytical Chemistry, 2020, 92, 7604−7611.
17. Chaomin Gao, Haihan Yu, Yanhu Wang, Dezhong Liu, Ting Wen, Lina Zhang, Shenguang Ge,* and Jinghua Yu, Paper-Based Constant Potential Electrochemiluminescence Sensing Platform with Black Phosphorus as a Luminophore Enabled by Perovskite Solar Cell, Analytical Chemistry, 2020, 92, 10, 6822-6826.
18.Chaomin Gao, Jie Xue, Lina Zhang, Peini Zhao, Kang Cui, Shenguang Ge*, Jinghua Yu, Paper based modification-free photoelectrochemical sensing platform with single-crystalline aloe like TiO2 as electron transporting material for cTnI detection, Biosensors and Bioelectronics, 2019, 131, 17–23.
19. Shaopeng Wang, Jinge Zhao, Yan Zhang, Mei Yan, Lina Zhang, Shenguang Ge*, Jinghua Yu, Photoelectrochemical Biosensor of HIV-1 Based on Cascaded Photoactive Materials and Triple-Helix Molecular Switch, Biosensors and Bioelectronics, 2019, 139, 111325
20. Fangfang Wang, Cuiping Fu, Chuan Huang, Na Li, Yanhu Wang, Shenguang Ge*, Jinghua Yu, Paper-based Closed Au-Bipolar Electrode Electrochemiluminescence Sensing Platform for the Detection of miRNA-155, Biosensors and Bioelectronics, 2020, 150, 111917.
代表性授权国家发明专利：
1. 一种基于功能化金属有机框架材料的电致化学发光传感器-（ZL 2017107568616）
2. 检测癌细胞表面多糖表达的光致电化学纸芯片的制备-（ZL2016105844890）
3. 癌细胞及细胞表面多糖检测荧光-比色双模式纸芯片的制备-（ZL2016103848365）
4. 一种金属有机框架材料表面负载分子印迹聚合物膜用于乙酰甲胺磷的电化学检测方法-（ZL2016106840064）
5. 一种化学发光光致电化学传感器的制备及有机磷类农药检测-（ZL2016106840007）
6. 一种基于便携式血糖仪检测凝血酶的纸分析器件的构建-（ZL2016109423424）
7. 点击化学技术制备分子印迹纸芯片传感器-（ZL201510480233.0）
8. 一种电聚合分子印迹聚合物中空通道纸器件的制备及在农药残留即时检测中的应用-（ZL201410436014.8）
9.用于叶酸过表达癌细胞快速检测的比色方法-（ZL201410124906.4)
10.一种基于点击化学仿生分子印迹电化学传感器的制备及对食品过敏原的检测-（ZL201210472177.2）
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[1]
2010.9 -- 2013.12
山东大学
化学
[2]
2003.9 -- 2006.7
济南大学
应用化学
[3]
1999.9 -- 2003.7
济南大学
应用化学
[1]
2017.12 -- 至今
济南大学
教授
[2]
2014.1 -- 2017.11
济南大学
副教授
[3]
2008.11 -- 2013.12
济南大学
讲师
