Fluorescent silicon nanoparticle–based quantitative hemin assay
- 发表刊物：Analytical and Bioanalytical Chemistry
- 关键字：Free hemin
Chiral silicon nanoparticles
Serum
Circular dichroism spectrum
Dynamic quenching
Inner flter efect
- 摘要：Hemin with functions such as oxygen carrying, oxygen storing, promoting redox, and performing electron transfer is important for the health of organisms. In this paper, green synthetic silicon nanoparticles (Si-NPs) were synthesized and used for
free hemin detection in serum (a low limit of detection (LOD), 29.5 nM). The quenching mechanism was investigated by
UV–vis absorption spectra, time-resolved luminescence decay curve, and circular dichroism (CD) spectra. It was confrmed
that multiple redox centers of hemin led to intensifed efective collision and increased the electron transfer rate, therefore
enhancing the dynamic quenching, and it was undeniable that the inner flter efect (IFE) also played a role in the quenching.
- 论文类型：SCI
- 是否译文：否
- 发表时间：2022-12-01
- 收录刊物：SCI
